A rigorous introduction to physical chemistry from a biological point of view. Thermodynamics is discussed with emphasis on the Gibbs free energy function and the concept of reaction eagerness. Due to the prevalence of water in living systems, aqueous solutions are treated in detail. The physical chemistry of biopolymers is discussed in conjunction with common molecular-weight determination methods including ultracentrifugation. Students are introduced to chemical kinetics in hands-on simulation sessions using an analog computer. Concurrent enrollment in 3140 required.